Enostim logo

The natural male enhancer

Enostim, natural sexual enhancer for men

Enostim™ is a unique and proprietary formulation of active ingredients, apple and grape polyphenols, enriched with saffron. 

3 synergistic benefits:

  • Blood flow enhancer: ENOs (endothelial Nitric Oxide synthase) synthetises NO which is directly implicated in blood flow. In vitro (1) and ex vivo (2) studies showed that Nexira’s proprietary formulation activates eNOs, which supports healthy blood flow and enhance sexual performance.
  • Saffron benefits: Historically, saffron (flower stigmas from Crocus sativus) has been used in traditional medicine. It was already consumed as an aphrodisiac by ancient Persians and Egyptians to enhance sexual performance.
  • Nitric Oxide protection: Nitric oxide has a short lifespan and is easily degraded by superoxide free radical. As shown in an in vivo study(3), the antioxidant molecules in EnoSTIM™ demonstrated the potential to specifically protect NO by decreasing oxidative stress by 74%.
  • Directions of use: 300-600 mg / day




(1) Effect of NPF on the activation of eNOs through the phosphorylation of “Serine 1177” from endothelial cells (HUVECs) as measured by flow cytometry. 2008.

(2) NPF stimulates endothelial-dependent healthy blood flow by nitric oxide synthesis. Ex vivo study on rat aorta. 

(3) The effects of NPF, a formulation containing grape and apple extracts and its effect on the production of peroxinitrites in hamsters subjected to aerobic physical activity. 2004